ea0016s17.4 | Thyroid cell biology | ECE2008
Dohan O
, Portulano C
, Basquin C
, Paroder M
, Nicola JP
, Maestas MJ
, Eskandari S
, Reyna-Neyra A
, Amzel LM
, Carrasco N
The Na+/I− symporter (NIS) is a key plasma membrane protein that mediates active I− uptake in the thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na+ per I−. In the thyroid, NIS-mediated I− uptake is the first step in the biosynthesis of the iodine-containing thyroid hormones, which are essential early in life for proper development of the central nerv...